課程名稱 |
神經電氣生理學 NEUROELETROPHYSIOLOGY |
開課學期 |
99-1 |
授課對象 |
生物資源暨農學院 獸醫學研究所 |
授課教師 |
張芳嘉 |
課號 |
VM5062 |
課程識別碼 |
629 U2040 |
班次 |
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學分 |
2 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
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上課地點 |
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備註 |
上課時間地點另訂。 總人數上限:20人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/991neurophysiol |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
This course will discuss the fundamental concept of electrophysiology, including basic electricity, neuronal properties and morphology, membrane potential, the passive properties of neuronal membrane, the generation of action potential, the microelectrode recording techniques (current clamp, voltage clamp and patch clamp recordings), ion channels and their kinetic properties (sodium channel, potassium channel and calcium channel), synaptic transmission, quantal properties of transmitter release, synaptic plasticity (long-term potentiation and long-term depression), and electroencephalogram (EEG) and electromyogram (EMG): the theory and their clinical applications. |
課程目標 |
1 Membrane Property
2 Membrane Potentials
3 Ion Channels: Passive membrane property
4 Ion Channels: Voltage-gate ion channels
5 Mechanisms of Transmitter Release
6 Synaptic Vehicle
7 Synaptic Transmission: Electrical or Chemical
8 Directly Gated Transmission at the Nerve-Muscle Synapse
9 Directly Gated Transmission at Central Synapse
10 Synaptic Transmission Mediated by Second Messengers
11 Small Molecules and Peptides
12 Synaptic Interaction and Synaptic Plasticity
13 Long-term potentiation & long-term depression
14 Techniques of Electrophysiology
15 Macroelectrophysiological technique: EEG & EMG
16 EEG & EMG application in seizure and sleep
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
1. Principle of Neural Science: by Eric Kandel, James H. Schwartz and Thomas M Jessel, Fourth Edition, McGraw-Hill Co., (2000)
2. The Physiology of Excitable cells: by David J. Aidley, Third Edition, Cambridge University Press, (1991)
3. From Neuron to Brain: by John G. Nicholls, A. Robert Martin and Bruce G. Wallace, Third Edition, Sinauer Associates, Inc., (1992).
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評量方式 (僅供參考) |
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週次 |
日期 |
單元主題 |
第1週 |
09/14 |
Introduction |
第2週 |
09/23 |
The Neuron/Membrane Potentials |
第3週 |
09/30 |
Passive membrane property |
第4週 |
10/07 |
The Action Potentials |
第5週 |
10/14 |
Recording Techniques/Ion Channels: Voltage-gate ion channels (I): Sodium Channel |
第6週 |
10/21 |
Ion Channels: Voltage-gate ion channels (II): Potassium & Calcium Channel |
第7週 |
10/28 |
Mechanisms of Transmitter Release & Synaptic Transmission |
第8週 |
11/04 |
Synaptic Plasticity/learning & memory |
第9週 |
11/11 |
MID-TERM EXAMINATION |
第10週 |
11/18 |
Macroelectrophysiology |
第11週 |
11/25 |
Functional anatomy of the central nervous system |
第12週 |
12/02 |
Sensory systems of the brain: sensory transduction, touch & pain |
第13週 |
12/09 |
Motor systems of the brain: reflex & voluntary movement |
第14週 |
12/16 |
Motor systems of the brain: basal ganglia/Neurophysiology basis of mood |
第15週 |
12/23 |
Debate I: Sleep helps memory consolidation |
第16週 |
12/30 |
Debate II: Should we manipulate our dreams? |
第17週 |
01/06 |
Debate III: Memory is no longer stored in brain in amnesia patients |
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